Application | Comment | Organism |
---|---|---|
medicine | enzymatic activities of functional COMT single-nucleotide polymorphisms in red blood cells in 24 healthy human volunteers, supplemented with750 mg of epigallocatechin-3-gallate.The homozygousVal-Met substitution in the SNPrs 4680 results in significantly decreased COMT activity. Enzymatic COMT activities are also affected by the other COMT polymorphisms. Epigallocatechin-3-gallate plasma levels significantly increase after intervention.They are not influenced by any of the COMT SNPs and different enzyme activities. Ingestion of 750 mg epigallocatechin-3-gallate does not result in impairment of COMT activity. However, COMT activity is significantly increased by 24% after epigallocatechin-3-gallate consumption | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epigallocatechin-3-gallate | inhibition in vitro. Supplementation with a high dose does not impair the activity of COMT | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |