Literature summary for 2.1.1.62 extracted from

Luzhkov, V.B.; Selisko, B.; Nordqvist, A.; Peyrane, F.; Decroly, E.; Alvarez, K.; Karlen, A.; Canard, B.; Qvist, J.
Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2O)-methyltransferase (2007), Bioorg. Med. Chem., 15, 7795-7802.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-[[3-(4-methylphenyl)adamant-1-yl]carbamoyl]-L-phenylalanine	0.1 mM, 75% inhibition. It is suggested that the inhibitor competes with the cofactor AdoMet and presumably also the capped RNA substrate	Dengue virus

Organism

Organism	UniProt	Comment	Textmining
Dengue virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 7MeGpppAC5	RNA substrate is used	Dengue virus	S-adenosyl-L-homocysteine + 7MeGpppA2'OMeC5	-	?

Synonyms

Synonyms	Comment	Organism
mRNA cap (nucleoside-2'O)-methyltransferase	-	Dengue virus
NS5MTaseDV	-	Dengue virus

Cofactor

Cofactor	Comment	Organism	Structure
AdoMet	-	Dengue virus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0605	-	-	Dengue virus	N-[[3-(4-methylphenyl)adamant-1-yl]carbamoyl]-L-phenylalanine

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Release 2023.1 (January 2023)