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Literature summary for 2.1.1.63 extracted from

  • Inoue, R.; Abe, M.; Nakabeppu, Y.; Sekiguchi, M.; Mori, T.; Suzuki, T.
    Characterization of human polymorphic DNA repair methyltransferase (2000), Pharmacogenetics, 10, 59-66.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coliKT233 and in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information three allelic variants: V1 with amino acid substitution Leu84Phe, variant V2 with amino acid substitution Trp65Cys and variant V3 with a silent mutation. Wild-type and V1 variant have similar enzymatic and physicochemical properties, while variant V2 is considered to be unstable and rare Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine Homo sapiens the enzyme is a critical defense against alkylation-induced mutagenesis and carcinogenesis DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 three allelic variants: V1, V2, and V3
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?
DNA containing 6-O-methylguanine + [protein]-L-cysteine the enzyme is a critical defense against alkylation-induced mutagenesis and carcinogenesis Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?