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Literature summary for 2.1.1.63 extracted from

  • Kanugula, S.; Pauly, G.T.; Moschel, R.C.; Pegg, A.E.
    A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities (2005), Proc. Natl. Acad. Sci. USA, 102, 3617-3622.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Ferroplasma acidarmanus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 4-O-methylthymine + [protein-L-cysteine Ferroplasma acidarmanus enzyme repairs O6-methylguanine lesions in DNA via alkyl transfer action DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Ferroplasma acidarmanus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Ferroplasma acidarmanus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 4-O-methylthymine + [protein-L-cysteine
-
Ferroplasma acidarmanus DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
?
DNA containing 4-O-methylthymine + [protein-L-cysteine enzyme repairs O6-methylguanine lesions in DNA via alkyl transfer action Ferroplasma acidarmanus DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
?

Synonyms

Synonyms Comment Organism
AGTendoV
-
Ferroplasma acidarmanus
O6-alkylguanine-DNA alkyltransferase
-
Ferroplasma acidarmanus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
46
-
-
Ferroplasma acidarmanus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
37 70 about 50% of maximal activitya at 37°C and at 70°C Ferroplasma acidarmanus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
-
Ferroplasma acidarmanus

pH Range

pH Minimum pH Maximum Comment Organism
6 7.6 pH 6.0: about 80% of maximal activity, pH 7.6: about 40% of maximal activity Ferroplasma acidarmanus