Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,2,3,4-diepoxybutane | induces AGT-DNA cross-linking, takes place exclusively at the cysteine residues within the protein | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | AGT-DNA cross-linking is a likely mechanism of 1,2,3,4-diepoxybutane-mediated cytotoxicity in cells expressing this important repair protein | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C145A | abolishes 1,2,3,4-diepoxybutane-induced cross-linking at this site, while the formation of conjugates via neighboring Cys150 is retained | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
AGT | - |
Homo sapiens |
O6-alkylguanine DNA alkyltransferase | - |
Homo sapiens |