Protein Variants | Comment | Organism |
---|---|---|
A121E | no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT | Homo sapiens |
A121T | no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT | Homo sapiens |
E166D | no major structural change upon energy minimization | Homo sapiens |
G132R | no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT | Homo sapiens |
G160R | no major structural change upon energy minimization, is in the vicinity of the active Cys145 and may cause disturbances of O6-alkyl transfer from DNA to the protein | Homo sapiens |
I143V | no major structural change upon energy minimization, is in the vicinity of the active Cys145 and may cause disturbances of O6-alkyl transfer from DNA to the protein, does not affect DNA repair capacity | Homo sapiens |
L84F | no major structural change upon energy minimization, may affect Zn2+ binding, does not affect DNA repair capacity | Homo sapiens |
additional information | examination of the structural changes accompanying single nucleotide polymorphisms-related amino-acid changes in the MGMT protein | Homo sapiens |
N123V | no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT | Homo sapiens |
W65C | no major structural change upon energy minimization, possibly unstable | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16455 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MGMT | - |
Homo sapiens |
O6-methylguanine-DNA methyltransferase | - |
Homo sapiens |