Application | Comment | Organism |
---|---|---|
medicine | MGMT can modulate cytotoxicity of camptothecin-derived topoisomerase I inhibitors, MGMT overexpression reveals more resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea, camptothecin, 7-ethyl-10-hydrocamptothecin and topotecan, alteration of MGMT expression coincides with camptothecin-induced cell death and poly(ADP-ribose) polymerase cleavage | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in CHO-derived Tet-on-inducible cells, knockdown of MGMT expression with small interfering RNA in HONE-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | no differences in protein levels and catalytic activity of topoisomerase I between MGMT-proficient and MGMT-deficient cells from the Tet-On-inducible and small interfering RNA systems | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-29 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
O6-methylguanine DNA methyltransferase | - |
Homo sapiens |