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Literature summary for 2.1.1.63 extracted from

  • Kuo, C.C.; Liu, J.F.; Chang, J.Y.
    DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors (2006), J. Pharmacol. Exp. Ther., 316, 946-954.
    View publication on PubMed

Application

Application Comment Organism
medicine MGMT can modulate cytotoxicity of camptothecin-derived topoisomerase I inhibitors, MGMT overexpression reveals more resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea, camptothecin, 7-ethyl-10-hydrocamptothecin and topotecan, alteration of MGMT expression coincides with camptothecin-induced cell death and poly(ADP-ribose) polymerase cleavage Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in CHO-derived Tet-on-inducible cells, knockdown of MGMT expression with small interfering RNA in HONE-1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information no differences in protein levels and catalytic activity of topoisomerase I between MGMT-proficient and MGMT-deficient cells from the Tet-On-inducible and small interfering RNA systems Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
O6-methylguanine DNA methyltransferase
-
Homo sapiens