Application | Comment | Organism |
---|---|---|
drug development | highly effective inactivation of MGMT by an oligodeoxyribonucleotide containing O6-(4-bromothenyl)guanine suggests that such oligodeoxyribonucleotides might have therapeutic applications if problems of delivery can be addressed | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpressed in Escherichia coli strain UC978 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | hydroxyethyl guanine-modified oligodeoxyribonucleotides are not effective inactivators of MGMT | Homo sapiens | |
O6-(4-bromothenyl)guanine | most potent inactivator described to date | Homo sapiens | |
O6-benzylguanine | - |
Homo sapiens | |
O6-methylguanine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 6-O-methylguanine + [protein]-L-cysteine | - |
Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MGMT | - |
Homo sapiens |
O6-methylguanine DNA methyltransferase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000001 | - |
- |
Homo sapiens | O6-(4-bromothenyl)guanine |