Literature summary for 2.1.1.63 extracted from

Zheng, M.; Bocangel, D.; Ramesh, R.; Ekmekcioglu, S.; Poindexter, N.; Grimm, E.A.; Chada, S.
Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells (2008), Mol. Cancer Ther., 7, 3842-3851.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	interleukin-24 down-regulates O6-methylguanine-DNA methyltransferase in melanoma cells, accumulation of functional p53 is essential for interleukin-24-induced down-regulation of O6-methylguanine-DNA methyltransferase	down
Homo sapiens	resistance to alkylating agents such as temozolomide correlates with increased expression of O6-methylguanine-DNA methyltransferase	up

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Release 2023.1 (January 2023)