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Literature summary for 2.1.1.63 extracted from

  • Chahal, M.; Abdulkarim, B.; Xu, Y.; Guiot, M.C.; Easaw, J.C.; Stifani, N.; Sabri, S.
    O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme (2012), Mol. Cancer Ther., 11, 2440-2450.
    View publication on PubMed
Search for more literature for 2.1.1.63

Cloned(Commentary)

Cloned (Comment) Organism
expressed in U-87MG cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
 x * 21000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-172 cell
-
 Homo sapiens
-
LN-18 cell
-
 Homo sapiens
-
T-98G cell
-
 Homo sapiens
-
U-138 cell
-
 Homo sapiens
-
U-251 cell
-
 Homo sapiens
-
U-373 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-benzylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-benzylguanine) + protein S-benzyl-L-cysteine
-
 ?
DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is a negative effector of glioblastoma multiforme invasion. Enzyme expression inversely correlates with angiogenesis and invasion in glioma Homo sapiens