Literature summary for 2.1.1.67 extracted from

Keizer-Garritsen, J.J.; Brouwer, C.; Lambooy, L.H.; Ter Riet, P.; Bokkerink, J.P.; Trijbels, F.J.; De Abreu, R.A.
Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children (2003), Ann. Clin. Biochem., 40, 86-93.

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Application

Application	Comment	Organism
analysis	monitoring of 6-thiopurine S-methyltransferase activity is especially important when patients are treated with 6-thiopurine drugs (drugs in treatment of acute lymphoblastic leukemia), since severe bone marrow toxicity may be induced if patients have deficient 6-thiopurine S-methyltransferase activity. The HPLC-based method enables the rapid screening of 6-6-thiopurine S-methyltransferase activities in patients treated with 6-thiopurines	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00665	-	S-adenosyl-L-methionine	Molt-F4 cell	Homo sapiens
0.0119	-	S-adenosyl-L-methionine	erythrocyte	Homo sapiens
0.0164	-	S-adenosyl-L-methionine	peripheral blood mononuclear cell	Homo sapiens
0.54	-	6-Mercaptopurine	erythrocyte	Homo sapiens
0.65	-	6-Mercaptopurine	Molt-F4 cell	Homo sapiens
0.85	-	6-Mercaptopurine	peripheral blood mononuclear cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-
MOLT-4F cell	-	Homo sapiens	-
peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 6-mercaptopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + 6-methylmercaptopurine	-	?

Synonyms

Synonyms	Comment	Organism
6-thiopurine S-methyltransferase	-	Homo sapiens
TPMT	-	Homo sapiens

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Release 2023.1 (January 2023)