Protein Variants | Comment | Organism |
---|---|---|
additional information | at least 23 single nucleotide polymorphisms in the TPMT gene have been identified that are associated with decreased or absent TPMT activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
median TPMT activities, Singapore Chinese 16.4 U, Singapore Malays 17.8 U, Singapore Indians 16.4 U, one unit of activity is defined as a formation of 1 nmol of 6-methylmercaptopurine per ml of packed red blood cells per h incubation at 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine methyltransferase | - |
Homo sapiens |
thiopurine S-methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |