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Literature summary for 2.1.1.67 extracted from

  • Lindqvist, M.; Skoglund, K.; Karlgren, A.; Soederkvist, P.; Peterson, C.; Kidhall, I.; Almer, S.
    Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23 (2007), Pharmacogenet. Genomics, 17, 891-895.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine individuals with decreased TPMT activity are at great risk for adverse reactions if treated with conventional thiopurine doses Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
for cloning of the TPMT fragment the TOPO TA cloning kit is used Homo sapiens

Protein Variants

Protein Variants Comment Organism
TPMT*23 polymorphism, single nucleotide substitution, C500G Homo sapiens
TPMT*3A polymorphism, single nucleotide substitutions, G460A and A719G Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens