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Literature summary for 2.1.1.67 extracted from

  • Schmiegelow, K.; Forestier, E.; Kristinsson, J.; Soederhaell, S.; Vettenranta, K.; Weinshilboum, R.; Wesenberg, F.; Wesenberg, F.
    Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study (2009), Leukemia, 23, 557-564.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 6-thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + 6-methylthiopurine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylthiopurine
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Homo sapiens
TPMT
-
Homo sapiens