Literature summary for 2.1.1.72 extracted from

Marinus, M.G.; Casadesus, J.
Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more (2009), FEMS Microbiol. Rev., 33, 488-503.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
S-adenosyl-L-methionine + DNA adenine	Brucella abortus	the DNA target sequence is GANTC	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Caulobacter vibrioides	the DNA target sequence is GANTC, CcrM is more active on hemimethylated than unmethylated DNA	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Escherichia coli	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Klebsiella pneumoniae	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Aeromonas hydrophila	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Salmonella enterica	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Vibrio cholerae serotype O1	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Yersinia enterocolitica	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Aggregatibacter actinomycetemcomitans	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Campylobacter jejuni	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	Pasteurella multocida	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Aeromonas hydrophila	-	-	-
Aggregatibacter actinomycetemcomitans	-	-	-
Brucella abortus	-	-	-
Campylobacter jejuni	-	-	-
Caulobacter vibrioides	-	-	-
Escherichia coli	-	-	-
Klebsiella pneumoniae	-	-	-
Pasteurella multocida	-	-	-
Salmonella enterica	-	serovar typhimurium	-
Vibrio cholerae serotype O1	-	-	-
Yersinia enterocolitica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GANTC	Brucella abortus	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GANTC, CcrM is more active on hemimethylated than unmethylated DNA	Caulobacter vibrioides	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Escherichia coli	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Klebsiella pneumoniae	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Aeromonas hydrophila	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Salmonella enterica	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Vibrio cholerae serotype O1	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Yersinia enterocolitica	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Aggregatibacter actinomycetemcomitans	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Campylobacter jejuni	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
S-adenosyl-L-methionine + DNA adenine	the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not	Pasteurella multocida	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?

Synonyms

Synonyms	Comment	Organism
CcrM	-	Caulobacter vibrioides
CcrM methylase	-	Brucella abortus
Dam methylase	-	Escherichia coli
Dam methylase	-	Klebsiella pneumoniae
Dam methylase	-	Aeromonas hydrophila
Dam methylase	-	Salmonella enterica
Dam methylase	-	Vibrio cholerae serotype O1
Dam methylase	-	Yersinia enterocolitica
Dam methylase	-	Aggregatibacter actinomycetemcomitans
Dam methylase	-	Campylobacter jejuni
Dam methylase	-	Pasteurella multocida
DNA adenine methyltransferase	-	Escherichia coli
DNA adenine methyltransferase	-	Brucella abortus
DNA adenine methyltransferase	-	Klebsiella pneumoniae
DNA adenine methyltransferase	-	Aeromonas hydrophila
DNA adenine methyltransferase	-	Salmonella enterica
DNA adenine methyltransferase	-	Caulobacter vibrioides
DNA adenine methyltransferase	-	Vibrio cholerae serotype O1
DNA adenine methyltransferase	-	Yersinia enterocolitica
DNA adenine methyltransferase	-	Aggregatibacter actinomycetemcomitans
DNA adenine methyltransferase	-	Campylobacter jejuni
DNA adenine methyltransferase	-	Pasteurella multocida

General Information

General Information	Comment	Organism
malfunction	a relevant defect of Yersinia enterocolitica Dam overproducers is enhanced invasion capacity, probably associated with transcriptional alterations in invasin genes inv and ail, and with changes in the composition of lipopolysaccharide O-antigen	Yersinia enterocolitica
malfunction	knockout of a putative DNA methyltransferase gene in Campylobacter jejuni causes reduced motility, aberrant flagellar appearance, and hyperadherence to epithelial cells, accompanied by reduced invasion	Campylobacter jejuni
malfunction	lack of Dam methylation causes partial attenuation upon intranasal or intraperitoneal inoculation of mice	Klebsiella pneumoniae
malfunction	mutants lacking Dam methylase are not viable, Dam overproduction does not impair bacterial growth	Vibrio cholerae serotype O1
physiological function	CcrM regulates the genes dnaA, ctrA, and ccrM at transcriptional level	Caulobacter vibrioides
physiological function	Dam methylation may control the expression of virulence genes	Pasteurella multocida
physiological function	DNA adenine methylation is involved in Aeromonas hydrophila pathogenesis	Brucella abortus
physiological function	DNA adenine methylation is involved in Aeromonas hydrophila pathogenesis	Aeromonas hydrophila
physiological function	the formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature, as a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Dam methylation regulates virulence genes at the posttranscriptional level	Salmonella enterica
physiological function	the formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature, as a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Dam methylation regulates virulence genes at the posttranscriptional level. Dam methylation plays a role in enterohemorrhagic Escherichia coli by controlling the production of the virulence factor Shiga toxin 2	Escherichia coli