Application | Comment | Organism |
---|---|---|
medicine | L-isoaspartyl residue formation in extracellular matrix proteins such as type -I collagen could play an important role in reducing cell migration. PIMT could be a therapeutic tool to restore normal cell migration in pathological conditions where cell motility is crucial | Drosophila sp. (in: flies) |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila sp. (in: flies) | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration | Drosophila sp. (in: flies) | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-isoaspartyl methyltransferase | - |
Drosophila sp. (in: flies) |