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Literature summary for 2.1.1.77 extracted from

  • Kosugi, S.; Furuchi, T.; Katane, M.; Sekine, M.; Shirasawa, T.; Homma, H.
    Suppression of protein L-isoaspartyl (D-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells (2008), Biochem. Biophys. Res. Commun., 371, 22-27.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)pLysS cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His GraviTrap column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.011
-
using the delta sleep-inducing peptide as the methyl acceptor Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + delta sleep-inducing peptide
-
Homo sapiens ?
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Synonyms

Synonyms Comment Organism
PIMT
-
Homo sapiens
protein L-isoaspartyl (D-aspartyl) methyltransferase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

General Information

General Information Comment Organism
malfunction PIMT-knockdown cells show significant accumulation of proteins with isomerized residues, compared to control cells Homo sapiens
physiological function PIMT repair of abnormal proteins is necessary to maintain normal mitogen-activated protein kinase signaling Homo sapiens