Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | from rat liver fed dietary pyridoxine ranging from adequate to deficient levels, 2-0 mg pyridoxine per kg diet. SHMT activity increases with increasing dietary pyridoxine concentrations | Rattus norvegicus | 5829 | - |
mitochondrion | from rat liver fed dietary pyridoxine ranging from adequate to deficient levels, 2-0 mg pyridoxine per kg diet. SHMT activity increases with increasing dietary pyridoxine concentrations. The mitochondrial isoenzyme comprises about 70% of the total activity | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O | Rattus norvegicus | the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake | tetrahydrofolate + L-Ser | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | from rats fed dietary pyridoxine ranging from adequare to deficient levels, 2-0 mg pyridoxine per kg diet | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O | the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake | Rattus norvegicus | tetrahydrofolate + L-Ser | - |
r |
Synonyms | Comment | Organism |
---|---|---|
serine hydroxymethyltransferase | - |
Rattus norvegicus |
SHMT | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Rattus norvegicus |