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Literature summary for 2.1.2.10 extracted from

  • Backofen, B.; Leeb, T.
    Genomic organization of the murine aminomethyltransferase gene (Amt) (2002), DNA Seq., 13, 179-183.
    View publication on PubMed
Search for more literature for 2.1.2.10

Application

Application Comment Organism
medicine a subset of nonketotic hyperglycinemia cases is due to mutations in the gene for the T-protein Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
Amt gene is located on chromosome 3p21 and contains 9 exons spanning about 6 kb of genomic sequence Homo sapiens
cloning and sequencing of the Amt gene with 9 closely spaced exons that are contained within about 5 kb of genomic DNA, encoding a protein of 403 amino acids, cis-acting promoter is likely to be very short, Amt gene may be localized on chromosome 9F Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information a subset of nonketotic hyperglycinemia cases is due to mutations in the gene for the T-protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate Homo sapiens
-
 dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
-
 ?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate Mus musculus important enzyme in glycine metabolism dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex Mus musculus ?
-
 ?
additional information enzyme is a component of the glycine cleavage system which is composed of P-, H-, L- and T-protein, multienzyme complex Homo sapiens ?
-
 ?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate
-
 Homo sapiens dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
-
 ?
S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate important enzyme in glycine metabolism Mus musculus dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3
-
 ?