General Stability | Organism |
---|---|
much less stable during storage in maleate buffer than in Tris or phosphate solutions | Gallus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Gallus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | precursors for inosinic acid biosynthesis | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus sp. | - |
chicken | - |
Purification (Comment) | Organism |
---|---|
- |
Gallus sp. |
Storage Stability | Organism |
---|---|
2°C, if the solution of purified enzyme are stored for 3 or 4 months, a requirement for a specific formyl donor can then be shown | Gallus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | precursors for inosinic acid biosynthesis | Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide | - |
Gallus sp. | N10-formyltetrahydrofolic acid + formylglycinamide ribonucleotide | - |
r | |
tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
r |