Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-formyl-5,6,7,8-tetrahydropteroylpenta-gamma-glutamate | - |
Gallus sp. | |
10-formylfolic acid pentaglutamate | competitive inhibitor | Gallus sp. | |
4-amino-10-methylpteroyl-gamma-glutamyl-gamma-glutamyl-gamma-glutamylglutamic acid | methotrexate polyglutamate, competitive inhibitor | Gallus sp. | |
4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Gallus sp. | |
5-amino-4-nitroimidazole ribonucleotide | - |
Mus musculus | |
5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Mus musculus | |
7,8-dihydropteroylpenta-gamma-glutamate | - |
Gallus sp. | |
dihydrofolic acid pentaglutamate | - |
Gallus sp. | |
folic acid pentaglutamate | competitive inhibitor | Gallus sp. | |
methotrexate | - |
Gallus sp. | |
pteroylpenta-gamma-glutamate | - |
Gallus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00023 | - |
tetrahydrofolic acid | - |
Gallus sp. | |
0.00051 | - |
10-formyldihydrofolic acid pentaglutamate | - |
Gallus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Mus musculus | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus sp. | - |
chicken | - |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially | Gallus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
liver | - |
Gallus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyl-7,8-dihydropteroylpenta-gamma-glutamate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide | - |
Gallus sp. | 7,8-dihydropteroylpenta-gamma-glutarate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
? | |
10-formyl-7,8-dihydropteroylpenta-gamma-L-glutamate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide | - |
Gallus sp. | dihydrofolic acid pentaglutamate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
? | |
10-formyldihydrofolic acid pentaglutamate + 5-aminoimidazole-4-carboxamide | - |
Gallus sp. | ? | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Mus musculus | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Mus musculus | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Mus musculus | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
5-amino-4-nitroimidazole ribonucleotide | - |
Mus musculus | |
0.00007 | - |
5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Mus musculus | |
0.00008 | - |
folic acid pentaglutamate | - |
Gallus sp. | |
0.00014 | - |
dihydrofolic acid pentaglutamate | - |
Gallus sp. | |
0.00137 | - |
10-formylfolic acid pentaglutamate | - |
Gallus sp. | |
0.00315 | - |
methotrexate polyglutamate | - |
Gallus sp. | |
0.075 | - |
methotrexate | - |
Gallus sp. |