Literature summary for 2.1.2.3 extracted from

Pastore, S.; Stocco, G.; Moressa, V.; Zandona, L.; Favretto, D.; Malusa, N.; Decorti, G.; Lepore, L.; Ventura, A.
5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis (2015), Rheumatol. Int., 35, 619-627.

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Application

Application	Comment	Organism
diagnostics	enzyme variants are used to predict methotrexate response in juvenile idiopathic arthritis, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene ATIC, genotyping of single nucleotide polymorphisms	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31939	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
5-aminoimidazole-4-carboxamide ribonucleotide-transformylase	-	Homo sapiens
ATIC	-	Homo sapiens
Bifunctional purine biosynthesis protein	-	Homo sapiens
PurH	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	the ATIC rs2372536 GG enzyme genotype is associated with improved clinical remission in juvenile idiopathic arthritis during methotrexate therapy, only one of the ATIC single nucleotide polymorphisms show any trend toward methotrexate response in an independent cohort of North American juvenile idiopathic arthritis children	Homo sapiens

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Release 2023.1 (January 2023)