Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.2.9 extracted from

  • Gambini, A.; Crosti, P.; Bianchetti, R.
    Inhibitor studies of methionyl-tRNA transformylase of Euglena gracilis (1980), Biochim. Biophys. Acta, 613, 73-78.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
10-Formylaminopterin 0.01 mM: 38% inhibition, 0.1 mM: 62% inhibition, competitive Euglena gracilis
10-formylpteroylglutamic acid 0.1 mM: 31% inhibition, 1 mM: 52% inhibition, competitive Euglena gracilis
5,10-methylenetetrahydrofolate
-
Euglena gracilis
5-formyltetrahydrofolate competitive inhibition Euglena gracilis
5-methyltetrahydrofolate most effective, non-competitive inhibitor Euglena gracilis
aminopterin 1 mM: 26% inhibition, competitive inhibition Euglena gracilis
methotrexate 0.01 mM: 30% inhibition, 0.1 mM, 52% inhibition, competitive Euglena gracilis
additional information inhibition studies, not inhibited by trimethoprim; not inhibited by folic acid Euglena gracilis
reduced aminopterin 1 mM, 34% inhibition, competitive inhibition Euglena gracilis
tetrahydrofolate competitive, multisite inhibition Euglena gracilis

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
Euglena gracilis 9507
-

Organism

Organism UniProt Comment Textmining
Euglena gracilis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O high specificity for initiator tRNAMet, strong positive cooperativity for Met-tRNAfMet and N10-formyltetrahydrofolate Euglena gracilis tetrahydrofolate + N-formylmethionyl-tRNAfMet
-
?

Cofactor

Cofactor Comment Organism Structure
10-formyltetrahydrofolate
-
Euglena gracilis
tetrahydrofolate
-
Euglena gracilis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
tetrahydrofolate
-
Euglena gracilis
0.003
-
5-methyltetrahydrofolate
-
Euglena gracilis
0.045
-
5-formyltetrahydrofolate
-
Euglena gracilis