Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-Formylaminopterin | 0.01 mM: 38% inhibition, 0.1 mM: 62% inhibition, competitive | Euglena gracilis | |
10-formylpteroylglutamic acid | 0.1 mM: 31% inhibition, 1 mM: 52% inhibition, competitive | Euglena gracilis | |
5,10-methylenetetrahydrofolate | - |
Euglena gracilis | |
5-formyltetrahydrofolate | competitive inhibition | Euglena gracilis | |
5-methyltetrahydrofolate | most effective, non-competitive inhibitor | Euglena gracilis | |
aminopterin | 1 mM: 26% inhibition, competitive inhibition | Euglena gracilis | |
methotrexate | 0.01 mM: 30% inhibition, 0.1 mM, 52% inhibition, competitive | Euglena gracilis | |
additional information | inhibition studies, not inhibited by trimethoprim; not inhibited by folic acid | Euglena gracilis | |
reduced aminopterin | 1 mM, 34% inhibition, competitive inhibition | Euglena gracilis | |
tetrahydrofolate | competitive, multisite inhibition | Euglena gracilis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chloroplast | - |
Euglena gracilis | 9507 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Euglena gracilis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O | high specificity for initiator tRNAMet, strong positive cooperativity for Met-tRNAfMet and N10-formyltetrahydrofolate | Euglena gracilis | tetrahydrofolate + N-formylmethionyl-tRNAfMet | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
10-formyltetrahydrofolate | - |
Euglena gracilis | |
tetrahydrofolate | - |
Euglena gracilis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
tetrahydrofolate | - |
Euglena gracilis | |
0.003 | - |
5-methyltetrahydrofolate | - |
Euglena gracilis | |
0.045 | - |
5-formyltetrahydrofolate | - |
Euglena gracilis |