Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | mTOR-dependent phosphorylation occurs at a site located between the dihydroorotase and aspartate transcarbamoylase domains | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
aspartate transcarbamoylase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | Rheb binds CAD in a GTP- and effector domain-dependent manner. The region of CAD where Rheb binds is located at the C-terminal region of the carbamoyl-phosphate synthetase domain and not in the dihydroorotase and aspartate transcarbamoylase domains. Rheb stimulated carbamoyl-phosphate synthetase activity of CAD in vitro. CAD binding is more pronounced with Rheb2 than with Rheb1 | Mus musculus |
physiological function | CAD protein, formed by carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase, is a multifunctional enzyme required for the de novo synthesis of pyrimidine nucleotides. Aspartate transcarbamoylase is located at the C-terminal part of CAD, Each activity is coded in a separate domain | Mus musculus |