Crystallization (Comment) | Organism |
---|---|
free enzyme and bound to carbamoyl phosphate or N-phosphonacetyl-L-aspartate | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D1958A | the mutant shows 2.5fold reduced activity compared to the wild type enzyme | Homo sapiens |
E1954A | the mutant shows 4fold reduced activity compared to the wild type enzyme | Homo sapiens |
R2024Q | the mutation virtually inactivates the enzyme, reducing the activity about 1000fold | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-phosphonacetyl-L-aspartate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbamoyl phosphate + L-aspartate | Homo sapiens | - |
phosphate + N-carbamoyl-L-aspartate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27708 | - |
- |
Purification (Comment) | Organism |
---|---|
HiTrap heparin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbamoyl phosphate + L-aspartate | - |
Homo sapiens | phosphate + N-carbamoyl-L-aspartate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotrimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ATCase | - |
Homo sapiens |
CAD | multienzymatic protein with three functional domains: glutamine-dependent carbamoyl phosphate synthetase, aspartate transcarbamoylase and dihydroorotase | Homo sapiens |