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Literature summary for 2.1.3.3 extracted from

  • Hoogenraad, N.J.
    Synthesis and properties of delta-N-(phosphonacetyl)-L-ornithine. A transition-state analog inhibitor of ornithine transcarbamylase (1978), Arch. Biochem. Biophys., 188, 137-144.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Delta-N-Phosphonoacetyl-L-ornithine synthesis and properties Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline ordered mechanism, carbamoylphosphate binds first Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
Rattus norvegicus phosphate + L-citrulline
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.27
-
delta-N-(phosphonoacetyl)-L-ornithine at 30°C and pH 7.4, competitive vs. carbamoyl phosphate, noncompetitive vs. ornithine Rattus norvegicus