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Literature summary for 2.1.3.3 extracted from

  • Templeton, M.D.; Reinhardt, L.A.; Collyer, C.A.; Mitchell, R.E.; Cleland, W.W.
    Kinetic analysis of the L-L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-L-ornithine (2005), Biochemistry, 44, 4408-4415.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Carbamoyl phosphate
-
 Pseudomonas savastanoi
diaminobutyric acid
-
 Pseudomonas savastanoi
L-norvaline
-
 Pseudomonas savastanoi
L-ornithine
-
 Pseudomonas savastanoi
phosphate competitive Pseudomonas savastanoi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 Carbamoyl phosphate pH 8.5, 37°C Pseudomonas savastanoi
1.1
-
 L-ornithine pH 8.5, 37°C Pseudomonas savastanoi
25
-
 L-lysine pH 8.5, 37°C Pseudomonas savastanoi
43.5
-
 Diaminobutane pH 8.5, 37°C Pseudomonas savastanoi

Organism

Organism UniProt Comment Textmining
Pseudomonas savastanoi
-
 pv. phaseolicola
-

Reaction

Reaction Comment Organism Reaction ID
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline ordered mechanism with carbamoyl phosphate first substrate to bind Pseudomonas savastanoi
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + diaminobutane
-
 Pseudomonas savastanoi phosphate + ?
-
 ?
carbamoyl phosphate + L-lysine
-
 Pseudomonas savastanoi phosphate + ?
-
 ?
carbamoyl phosphate + L-ornithine
-
 Pseudomonas savastanoi phosphate + L-citrulline
-
 ?

Synonyms

Synonyms Comment Organism
ROTCase
-
 Pseudomonas savastanoi

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0036
-
 L-lysine pH 8.5, 37°C Pseudomonas savastanoi
0.025
-
 Diaminobutane pH 8.5, 37°C Pseudomonas savastanoi
49
-
 L-ornithine pH 8.5, 37°C Pseudomonas savastanoi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.151
-
 Carbamoyl phosphate pH 8.5, 37°C Pseudomonas savastanoi
1.1
-
 diaminobutyric acid pH 8.5, 37°C Pseudomonas savastanoi
1.7
-
 L-norvaline pH 8.5, 37°C Pseudomonas savastanoi
1.9
-
 L-ornithine pH 8.5, 37°C Pseudomonas savastanoi
3.8
-
 phosphate pH 8.5, 37°C Pseudomonas savastanoi