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Literature summary for 2.1.3.3 extracted from

  • Zhao, W.; Zhou, X.; Lu, Y.; Peng, Y.; Lin, Z.; Lin, J.; Yang, L.; Yin, X.; Zhao, D.
    Mycobacterium bovis ornithine carbamoyltransferase, MB1684, induces proinflammatory cytokine gene expression by activating NF-kappaB in macrophages (2014), DNA Cell Biol., 33, 311-319.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene MB1684, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)pLysS Mycobacterium tuberculosis variant bovis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
x * 39000, untagged enzyme, SDS-PAGE, x * 41000, recombinant His-tagged enzyme, SDS-PAGE Mycobacterium tuberculosis variant bovis
41000
-
x * 39000, untagged enzyme, SDS-PAGE, x * 41000, recombinant His-tagged enzyme, SDS-PAGE Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-ornithine Mycobacterium tuberculosis variant bovis
-
phosphate + L-citrulline
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis variant bovis P0A5M9 gene MB1684
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3)pLysS by nickel affinity chromatography Mycobacterium tuberculosis variant bovis

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
Mycobacterium tuberculosis variant bovis phosphate + L-citrulline
-
?

Subunits

Subunits Comment Organism
? x * 39000, untagged enzyme, SDS-PAGE, x * 41000, recombinant His-tagged enzyme, SDS-PAGE Mycobacterium tuberculosis variant bovis

Synonyms

Synonyms Comment Organism
carbamoyltransferase
-
Mycobacterium tuberculosis variant bovis
MB1684
-
Mycobacterium tuberculosis variant bovis

General Information

General Information Comment Organism
physiological function the enzyme induces proinflammatory cytokine gene expression by activating NF-kappaB in macrophages of the bovine host. The enzyme plays a role in induction of upregulation of interferon-gamma and proinflammatory cytokines (interleukin-1beta, IL-6, and tumor necrosis factor-alpha) in Bos taurus Ana-1 macrophages Mycobacterium tuberculosis variant bovis