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Literature summary for 2.1.4.1 extracted from
- AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review (2008), J. Inherit. Metab. Dis., 31, 230-239.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | creatine deficiency syndromes, either due to AGAT, GAMT or SLC6A8 deficiencies, lead to a complete absence, or a very strong decrease, of creatine within the brain | Mammalia |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + glycine | Mammalia | - |
L-ornithine + guanidinoacetate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mammalia | - |
| central nervous system | - |
Mammalia | - |
| kidney | - |
Mammalia | - |
| liver | - |
Mammalia | - |
| pancreas | - |
Mammalia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + glycine | - |
Mammalia | L-ornithine + guanidinoacetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGAT | - |
Mammalia |
| arginine:glycine amidinotransferase | - |
Mammalia |
| glycine amidinotransferase | - |
Mammalia |
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