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Literature summary for 2.2.1.1 extracted from
- Is transketolase like 1 a target for the treatment of differentiated thyroid carcinoma? A study on thyroid cancer cell lines (2009), Invest. New Drugs, 27, 297-303.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | TKTL 1 is highest expressed in cell lines derived from more invasive tumors but the expression level is not strongly correlated to proliferation rate, to GLUT-1 expression or to the response to oxythiamine. Overexpression of TKTL-1 is not an indicator for responsiveness to oxythiamine | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| oxythiamine | shows only a weak effect in TKTL-1 expressing cell lines | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| FTC-133 cell | - |
Homo sapiens | - |
| additional information | in ONCO-DG-1 cells TKTL-1 is highly expressed. Present in FTC-238 cells and CGTH-W-1 cells. TKTL-1 is absent from normal thyrocytes | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TKTL-1 | - |
Homo sapiens |
| transketolase like 1 | - |
Homo sapiens |
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