Literature summary for 2.2.1.1 extracted from

Lovato, L.; Cianti, R.; Gini, B.; Marconi, S.; Bianchi, L.; Armini, A.; Anghileri, E.; Locatelli, F.; Paoletti, F.; Franciotta, D.; Bini, L.; Bonetti, B.
Transketolase and CNPase I are specifically recognized by IgG autoantibodies in multiple sclerosis patients (2008), Mol. Cell. Proteomics, 7, 2337-2349.

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Application

Application	Comment	Organism
medicine	transketolase may emerge as a target of multiple sclerosis cerebro-spinal fluid autoimmune response	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29401	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	at the lesion border	Homo sapiens	-
brain	in normal human brain transketolase is expressed on almost the totality of mature oligodendrocytes and scattered NG2-positive precursors, diffusely on ependymal cells and on distinct subsets of neuronal populations	Homo sapiens	-
cerebral white matter	normal and multiple sclerosis samples	Homo sapiens	-
macrophage	at the lesion border	Homo sapiens	-
monocyte	at the lesion border	Homo sapiens	-
additional information	diffuse expression of transketolase in ependymal cells of normal human brain. At the lesion border transketolase is expressed by oligodendrocyte precursors (NG2-positive precursor)	Homo sapiens	-
oligodendrocyte	transketolase is mainly expressed by oligodendrocytes in normal conditions, but is also present in oligodendrocytes in normal appearing white matter around multiple sclerosis plaques	Homo sapiens	-

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Release 2023.1 (January 2023)