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Literature summary for 2.2.1.5 extracted from
- Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase (2010), Chem. Biol., 17, 323-332.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | strictly dependent on | Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mycobacterium tuberculosis | catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) | ? | - |
? | |
| additional information | Mycobacterium tuberculosis | Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate | ? | - |
? | |
| additional information | Mycobacterium tuberculosis H37Rv | catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) | ? | - |
? | |
| additional information | Mycobacterium tuberculosis H37Rv | Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WIS5 | protein is originally annotated as the alpha-ketoglutarate (alpha-KG) decarboxylase (E1) component of alpha-KG dehydrogenase complex. The physiological activity of Rv1248c as that of a carboligase established by activity-based metabolomic profiling | - |
| Mycobacterium tuberculosis H37Rv | P9WIS5 | protein is originally annotated as the alpha-ketoglutarate (alpha-KG) decarboxylase (E1) component of alpha-KG dehydrogenase complex. The physiological activity of Rv1248c as that of a carboligase established by activity-based metabolomic profiling | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + glyoxylate | - |
Mycobacterium tuberculosis | 2-hydroxy-3-oxoadipate + CO2 | - |
? | |
| 2-oxoglutarate + glyoxylate | - |
Mycobacterium tuberculosis H37Rv | 2-hydroxy-3-oxoadipate + CO2 | - |
? | |
| additional information | catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
| additional information | Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
| additional information | enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-hydroxy-3-oxoadipate synthase | - |
Mycobacterium tuberculosis |
| carboligase | - |
Mycobacterium tuberculosis |
| HOA synthase | - |
Mycobacterium tuberculosis |
| Rv1248c | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | strictly dependent on | Mycobacterium tuberculosis | |
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