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Literature summary for 2.2.1.6 extracted from

  • Wang, J.G.; Lee, P.K.; Dong, Y.H.; Pang, S.S.; Duggleby, R.G.; Li, Z.M.; Guddat, L.W.
    Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase (2009), FEBS J., 276, 1282-1290.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide and methyl 2-([(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate, to 3.0 A and 2.8 A resolution, respectively. In both complexes, the inhibitors are bound in the tunnel leading to the active site, such that the sole substituent of the heterocyclic ring is buried deepest and oriented towards the thiamine diphosphate. The cofactor is intact and present most likely as the hydroxylethyl intermediate Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
methyl 2-([(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate
-
Arabidopsis thaliana
N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide
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Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P17597
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-