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Literature summary for 2.2.1.6 extracted from

  • Dasari, S.; Koelling, R.
    Cytosolic localization of acetohydroxyacid synthase Ilv2 and its impact on diacetyl formation during beer fermentation (2011), Appl. Environ. Microbiol., 77, 727-731.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
brewing unpleasant butterscotch-like flavor in beer due to accumulation of 2,3-butanedione derives from accumulation of mitochondrial matrix-targeted acetohydroxyacid synthase Ilv2 preprotein in the cytosol. Ilv2 preprotein accumulates in the cytosol of petite yeasts. Expression of a mutant allele of the gamma-subunit of the F1-ATPase, ATP3-5, could be an attractive way to reduce diacetyl formation by petite strains Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information expression of an Ilv2 variant that lacks the N-terminal mitochondrial targeting sequence leads to highly elevated diacetyl levels comparable to a petite strain. Expression of a mutant allele of the gamma-subunit of the F1-ATPase, ATP3-5, could be an attractive way to reduce diacetyl formation by petite strains Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Saccharomyces cerevisiae 5739
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
petite mutant
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme contains a N-terminal mitochondrial targeting sequence Saccharomyces cerevisiae