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Literature summary for 2.2.1.7 extracted from

  • Mao, J.; Eoh, H.; He, R.; Wang, Y.; Wan, B.; Franzblau, S.G.; Crick, D.C.; Kozikowski, A.P.
    Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase (2008), Bioorg. Med. Chem. Lett., 18, 5320-5323.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.7

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
2-methyl-3,5-diphenyl-6-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
2-methyl-5-naphthalen-2-yl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3,5-bis(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3,5-diphenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-bromophenyl)-5-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-bromophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-2-ethyl-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-2-methyl-5-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-5-(methoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-chlorophenyl)-5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-methoxyphenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
3-(4-methoxyphenyl)-5-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
5-(chloromethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
5-benzyl-3-(4-chlorophenyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
5-benzyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
5-benzyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
6-benzyl-3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Mycobacterium tuberculosis
ethyl (5-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate
-
 Mycobacterium tuberculosis
methyl [3-(4-bromophenyl)-7-oxo-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl]acetate
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
67800
-
 SDS-PAGE Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
95% pure by SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
1-deoxy-D-xylulose 5-phosphate synthase
-
 Mycobacterium tuberculosis
DXS
-
 Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0106
-
-
 Mycobacterium tuberculosis 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0109
-
-
 Mycobacterium tuberculosis 3-(4-chlorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.014
-
-
 Mycobacterium tuberculosis 5-benzyl-3-(4-chlorophenyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0195
-
-
 Mycobacterium tuberculosis 2-methyl-5-naphthalen-2-yl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0197
-
-
 Mycobacterium tuberculosis 3-(4-chlorophenyl)-2-ethyl-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0202
-
-
 Mycobacterium tuberculosis 3-(4-methoxyphenyl)-5-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.023
-
-
 Mycobacterium tuberculosis 3,5-diphenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0306
-
-
 Mycobacterium tuberculosis 2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0342
-
-
 Mycobacterium tuberculosis 3-(4-chlorophenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0411
-
-
 Mycobacterium tuberculosis 3-(4-chlorophenyl)-5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0424
-
-
 Mycobacterium tuberculosis 3,5-bis(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0535
-
-
 Mycobacterium tuberculosis 3-(4-bromophenyl)-5-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0551
-
-
 Mycobacterium tuberculosis 3-(4-chlorophenyl)-2-methyl-5-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0637
-
-
 Mycobacterium tuberculosis 5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0711
-
-
 Mycobacterium tuberculosis 5-benzyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0719
-
-
 Mycobacterium tuberculosis 2-methyl-3,5-diphenyl-6-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.073
-
-
 Mycobacterium tuberculosis methyl [3-(4-bromophenyl)-7-oxo-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl]acetate
0.0907
-
-
 Mycobacterium tuberculosis 3-(4-methoxyphenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.0984
-
-
 Mycobacterium tuberculosis 3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.1141
-
-
 Mycobacterium tuberculosis 5-benzyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis 3-(4-methoxyphenyl)-5-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis 3-(4-chlorophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis 3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis ethyl (5-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate
0.2
-
 value above Mycobacterium tuberculosis 5-(chloromethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis 3-(4-bromophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis 6-benzyl-3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
-
 value above Mycobacterium tuberculosis 3-(4-chlorophenyl)-5-(methoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one