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Literature summary for 2.2.1.7 extracted from

  • Bartee, D.; Morris, F.; Al-Khouja, A.; Freel Meyers, C.L.
    Hydroxybenzaldoximes are D-GAP-competitive inhibitors of E. coli 1-deoxy-D-xylulose-5-phosphate synthase (2015), ChemBioChem, 16, 1771-1781.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.7

Inhibitors

Inhibitors Comment Organism Structure
(1E,1'E)-O,O'-(ethane-1,2-diyl)bis[2,4,5-trihydroxybenzaldehyde oxime]
-
 Escherichia coli
(1E,7E)-1-(2,4,5-trihydroxyphenyl)-3,6-dioxa-2,7-diazanona-1,7-dien-9-oate
-
 Escherichia coli
(E)-2,4,5-trihydroxybenzaldehyde O-benzyl oxime
-
 Escherichia coli
(E)-2,4,5-trihydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-2,4,5-trihydroxybenzaldehyde oxime
-
 Escherichia coli
(E)-2,4-dihydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-2,5-dihydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-2-fluoro-4,5-dihydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-2-fluoro-4,5-dimethoxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-2-hydroxy-3-nitrobenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-2-hydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-3,4,5-trihydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-3,4-dihydroxy-5-methoxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-4,5-difluoro-2-hydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-4-hydroxy-3-nitrobenzaldehyde O-methyl oxime
-
 Escherichia coli
(E)-5-[(2-methylhydrazono)methyl]benzene-1,2,4-triol
-
 Escherichia coli
(E)-uracil-6-carbaldehyde O-methyl oxime
-
 Escherichia coli
(E,Z)-2,4,5-trimethoxybenzaldehyde O-methyl oxime
-
 Escherichia coli
(E,Z)-3,4-dihydroxybenzaldehyde O-methyl oxime
-
 Escherichia coli
5-[(methoxyamino)methyl]benzene-1,2,4-triol
-
 Escherichia coli
butyl acetyl phosphonate
-
 Escherichia coli
ketoclomazone
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + D-glyceraldehyde 3-phosphate Escherichia coli
-
 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + D-glyceraldehyde 3-phosphate
-
 Escherichia coli 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
1-deoxy-D-xylulose 5-phosphate synthase
-
 Escherichia coli
DXP synthase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 (1E,1'E)-O,O'-(ethane-1,2-diyl)bis[2,4,5-trihydroxybenzaldehyde oxime] at pH 8.0 and 37°C Escherichia coli
0.0026
-
 (E)-2,4,5-trihydroxybenzaldehyde oxime at pH 8.0 and 37°C Escherichia coli
0.0039
-
 (E)-2,4,5-trihydroxybenzaldehyde O-methyl oxime at pH 8.0 and 37°C Escherichia coli
0.0056
-
 butyl acetyl phosphonate at pH 8.0 and 37°C Escherichia coli
0.0091
-
 (E)-2,4,5-trihydroxybenzaldehyde O-benzyl oxime at pH 8.0 and 37°C Escherichia coli
0.0151
-
 (E)-2-fluoro-4,5-dihydroxybenzaldehyde O-methyl oxime at pH 8.0 and 37°C Escherichia coli
0.0184
-
 (1E,7E)-1-(2,4,5-trihydroxyphenyl)-3,6-dioxa-2,7-diazanona-1,7-dien-9-oate at pH 8.0 and 37°C Escherichia coli
0.0294
-
 (E)-3,4,5-trihydroxybenzaldehyde O-methyl oxime at pH 8.0 and 37°C Escherichia coli
0.0478
-
 (E)-2-hydroxy-3-nitrobenzaldehyde O-methyl oxime at pH 8.0 and 37°C Escherichia coli
0.075
-
 ketoclomazone at pH 8.0 and 37°C Escherichia coli
0.075
-
 5-[(methoxyamino)methyl]benzene-1,2,4-triol Ki above 0.075 mM, at pH 8.0 and 37°C Escherichia coli
0.075
-
 (E)-5-[(2-methylhydrazono)methyl]benzene-1,2,4-triol Ki above 0.075 mM, at pH 8.0 and 37°C Escherichia coli
0.1
-
 (E,Z)-2,4,5-trimethoxybenzaldehyde O-methyl oxime Ki above 0.1 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E,Z)-3,4-dihydroxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-2-hydroxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-2,5-dihydroxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-2,4-dihydroxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-3,4-dihydroxy-5-methoxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-uracil-6-carbaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-4-hydroxy-3-nitrobenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-4,5-difluoro-2-hydroxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli
0.2
-
 (E)-2-fluoro-4,5-dimethoxybenzaldehyde O-methyl oxime Ki above 0.2 mM, at pH 8.0 and 37°C Escherichia coli