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Literature summary for 2.2.1.8 extracted from

  • Murphy, C.D.; O'Hagan, D.; Schaffrath, C.
    Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya (2001), Angew. Chem., 40, 4479-4481.
    View publication on PubMed
Search for more literature for 2.2.1.8

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 2 * 60000, SDS-PAGE Streptomyces cattleya
120000
-
 gel filtration Streptomyces cattleya

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-threonine + fluoroacetaldehyde Streptomyces cattleya enzyme is important in biosynthesis of 4-fluorothreonine acetaldehyde + 4-fluoro-L-threonine
-
 ?
L-threonine + fluoroacetaldehyde Streptomyces cattleya NRRL 8057 enzyme is important in biosynthesis of 4-fluorothreonine acetaldehyde + 4-fluoro-L-threonine
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces cattleya
-
 NRRL 8057
-
Streptomyces cattleya NRRL 8057
-
 NRRL 8057
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces cattleya

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonine + fluoroacetaldehyde the enzyme-PLP complex accepts acetaldehyde as a substrate and generates a new molecule of threonine in a neutral crossover reaction Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
-
 ?
L-threonine + fluoroacetaldehyde enzyme is important in biosynthesis of 4-fluorothreonine Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
-
 ?
L-threonine + fluoroacetaldehyde the enzyme-PLP complex accepts acetaldehyde as a substrate and generates a new molecule of threonine in a neutral crossover reaction Streptomyces cattleya NRRL 8057 acetaldehyde + 4-fluoro-L-threonine
-
 ?
L-threonine + fluoroacetaldehyde enzyme is important in biosynthesis of 4-fluorothreonine Streptomyces cattleya NRRL 8057 acetaldehyde + 4-fluoro-L-threonine
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 60000, SDS-PAGE Streptomyces cattleya

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate pyridoxal 5'-phosphate protein Streptomyces cattleya