Literature summary for 2.2.1.8 extracted from

Zhao, C.; Li, P.; Deng, Z.; Ou, H.Y.; McGlinchey, R.P.; OHagan, D.
Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants (2012), Bioorg. Chem., 44, 1-7.

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces cattleya	F8JMF0	gene is located on the megaplasmid	-
Streptomyces cattleya DSM 46488	F8JMF0	gene is located on the megaplasmid	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fluoroacetaldehyde + L-threonine	-	Streptomyces cattleya	acetaldehyde + 4-fluoro-L-threonine	-	?
fluoroacetaldehyde + L-threonine	-	Streptomyces cattleya DSM 46488	acetaldehyde + 4-fluoro-L-threonine	-	?

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Streptomyces cattleya

General Information

General Information	Comment	Organism
physiological function	gene disruption of the transaldolase results in a mutant which can produce fluoroacetate but is blocked in its ability to biosynthesise 4-fluorothreonine, revealing a branchpoint role for the PLP-transaldolase	Streptomyces cattleya

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Release 2023.1 (January 2023)