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Literature summary for 2.3.1.108 extracted from

  • Wang, B.; Rao, Y.H.; Inoue, M.; Hao, R.; Lai, C.H.; Chen, D.; McDonald, S.L.; Choi, M.C.; Wang, Q.; Shinohara, M.L.; Yao, T.P.
    Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production (2014), Nat. Commun., 5, 3479.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide macrophages challenged by bacterial lipopolysaccharides undergo extensive microtubule acetylation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function macrophages challenged by bacterial lipopolysaccharides undergo extensive microtubule acetylation. Suppression of lipopolysaccharide-induced microtubule acetylation by inactivating the tubulin acetyltransferase, MEC17, profoundly inhibits the induction of anti-inflammatory interlukin-10, a phenotype effectively reversed by an acetylation-mimicking alpha-tubulin mutant. Reversible microtubule acetylation is a kinase signaling modulator and a key component in the inflammatory response Mus musculus