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Literature summary for 2.3.1.108 extracted from

  • Montagnac, G.; Meas-Yedid, V.; Irondelle, M.; Castro-Castro, A.; Franco, M.; Shida, T.; Nachury, M.V.; Benmerah, A.; Olivo-Marin, J.C.; Chavrier, P.
    alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits (2013), Nature, 502, 567-570.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
clathrin-coated vesicle
-
Homo sapiens 30136
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q5SQI0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function clathrin-coated pits control microtubule acetylation through a direct interaction of the alpha-tubulin acetyltransferase alphaTAT1 with the clathrin adaptor AP-2. About one-third of growing microtubule (+) ends contacts and pauses at clathrin-coated pits and loss of clathrin-coated pits decreased tubulin K40 acetylation levels. alphaTAT1 localises to clathrin-coated pits through a direct interaction with AP-2 that is required for microtubule acetylation. In migrating cells, the polarized orientation of acetylated microtubules correlates with clathrin-coated pits accumulation at the leading edge 10, and interaction of alphaTAT1 with AP-2 is required for directional migration Homo sapiens