Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
clathrin-coated vesicle | - |
Homo sapiens | 30136 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5SQI0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | clathrin-coated pits control microtubule acetylation through a direct interaction of the alpha-tubulin acetyltransferase alphaTAT1 with the clathrin adaptor AP-2. About one-third of growing microtubule (+) ends contacts and pauses at clathrin-coated pits and loss of clathrin-coated pits decreased tubulin K40 acetylation levels. alphaTAT1 localises to clathrin-coated pits through a direct interaction with AP-2 that is required for microtubule acetylation. In migrating cells, the polarized orientation of acetylated microtubules correlates with clathrin-coated pits accumulation at the leading edge 10, and interaction of alphaTAT1 with AP-2 is required for directional migration | Homo sapiens |