Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Nitro-2-naphthol | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
coenzyme A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
iodoacetamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | no inhibition by 2,6-dichloro-4-nitrophenol, chloramphenicol, hydroxylamine; no inhibition by paraoxon | Salmonella enterica subsp. enterica serovar Typhimurium | |
N-ethylmaleimide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
p-chloromercuribenzoate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Pentachlorophenol | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
thiolactomycin | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0033 | - |
acetyl-CoA | reaction with O-acetyl transfer to 2-hydroxyamino-6-methyldipyrido[1,2-alpha: 3',2'-d]imidazole as substrate | Salmonella enterica subsp. enterica serovar Typhimurium |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
gel filtration | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an N-hydroxyarylamine | Salmonella enterica subsp. enterica serovar Typhimurium | involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species | CoA + an N-acetoxyarylamine | - |
? | |
acetyl-CoA + an N-hydroxyarylamine | Salmonella enterica subsp. enterica serovar Typhimurium | the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates | CoA + an N-acetoxyarylamine | - |
? | |
acetyl-CoA + an N-hydroxyarylamine | Salmonella enterica subsp. enterica serovar Typhimurium | unknown endogenous substrate in bacteria | CoA + an N-acetoxyarylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium TA98 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial, by ammonium sulfate precipitation, DEAE-cellulose and Sephadex-G150 column chromatography | Salmonella enterica subsp. enterica serovar Typhimurium |
streptomycin, ammonium sulfate precipitation, DEAE Cellulose, Sephadex G-150 chromatograpy | Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.126 | - |
2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole as substrate | Salmonella enterica subsp. enterica serovar Typhimurium |
Storage Stability | Organism |
---|---|
-80°C, at least 3 months | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | N-hydroxy-2-acetylaminofluorene cannot replace acetyl-CoA | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? | |
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | N-hydroxy-2-acetylaminofluorene cannot replace acetyl-CoA | Salmonella enterica subsp. enterica serovar Typhimurium TA98 | CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? | |
acetyl-CoA + 3-hydroxyamino-1-methyl-pyrido[4,3-b]-indole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-acetoxy-amino-1-methyl-pyrido[4,3-b]-indole | - |
? | |
acetyl-CoA + an N-hydroxyarylamine | involved in mutagenic, metabolic activation of carcinogenic arylamines to form DNA-binding species | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + an N-acetoxyarylamine | - |
? | |
acetyl-CoA + an N-hydroxyarylamine | the enzyme from liver, but not from bacteria, can also catalyse acetylation of arylamines and N,O-acetylation of arylhydroxamates | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + an N-acetoxyarylamine | - |
? | |
acetyl-CoA + an N-hydroxyarylamine | unknown endogenous substrate in bacteria | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + an N-acetoxyarylamine | - |
? | |
acetyl-CoA + N-hydroxy-2-aminofluorene | - |
Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-acetoxy-2-aminofluorene | - |
? | |
butyryl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 11% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-(butyryloxy)-6-methylpyrido[3',2':4,5]imidazo[1,2-a]pyridin-2-amine | - |
? | |
butyryl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 11% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium TA98 | CoA + N-(butyryloxy)-6-methylpyrido[3',2':4,5]imidazo[1,2-a]pyridin-2-amine | - |
? | |
hexanoyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 1.3% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-hexanoyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? | |
malonyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 19% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-malonyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? | |
malonyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 19% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium TA98 | CoA + N-malonyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? | |
additional information | the N-acetoxyarylamine products form covalent adducts with cellular macromolecules, e.g. tRNA | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
additional information | the N-acetoxyarylamine products form covalent adducts with cellular macromolecules, e.g. tRNA | Salmonella enterica subsp. enterica serovar Typhimurium TA98 | ? | - |
? | |
propionyl-CoA + 2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 89% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium | CoA + N-propionyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? | |
propionyl-CoA + 2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | 89% of the activity compared to acetyl-CoA as acyl donor | Salmonella enterica subsp. enterica serovar Typhimurium TA98 | CoA + N-propionyloxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole | - |
? |