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Literature summary for 2.3.1.12 extracted from

  • Willms, C.R.; Oliver, R.M.; Henney, H.R.; Mukherjee, B.B.; Reed, L.J.
    alpha-Keto acid dehydrogenase complexes. VI. Dissociation and reconstitution of the dihydrolipoyl transacetylase of Escherichia coli (1967), J. Biol. Chem., 242, 889-897.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 2 * 36000, in the presence of dilute acetic acid Escherichia coli
1470000
-
 sedimentation equilibrium experiments in 0.83 M acetic and and 0.005 M sodium chloride Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydrolipoamide + acetyl-CoA Escherichia coli
-
 S-acetyldihydrolipoamide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Renatured (Commentary)

Renatured (Comment) Organism
treatment with dilute acetic acid solution results in dissociation into inactive subunits with MW 70000, removal of the acid results in restoration of enzymatic activity Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrolipoamide + acetyl-CoA
-
 Escherichia coli S-acetyldihydrolipoamide + CoA
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 36000, in the presence of dilute acetic acid Escherichia coli