Literature summary for 2.3.1.12 extracted from

Jackson, J.C.; Vinluan, C.C.; Dragland, C.J.; Sundararajan, V.; Yan, B.; Gounarides, J.S.; Nirmala, N.R.; Topiol, S.; Ramage, P.; Blume, J.E.; Aicher, T.D.; Bell, P.A.; Mann, W.R.
Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex, Identification of important amino acid residues (1998), Biochem. J., 334, 703-711.

No PubMed abstract available

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F231A	ability to be post-translationally lipoylated remains	Homo sapiens
I229A	ability to be post-translationally lipoylated remains	Homo sapiens
I229A/F231A	ability to be post-translationally lipoylated remains, far-UV CD spectrum differs from wild-type enzyme	Homo sapiens
L189A	ability to be post-translationally lipoylated remains	Homo sapiens
M194A	ability to be post-translationally lipoylated remains	Homo sapiens
M197A	ability to be post-translationally lipoylated remains	Homo sapiens
V188A	ability to be post-translationally lipoylated remains, far-UV CD spectrum differs from wild-type enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dihydrolipoamide + acetyl-CoA	Homo sapiens	-	S-acetyldihydrolipoamide + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydrolipoamide + acetyl-CoA	-	Homo sapiens	S-acetyldihydrolipoamide + CoA	-	?

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Release 2023.1 (January 2023)