Crystallization (Comment) | Organism |
---|---|
structures of apo protein, substrate complex with UDP-GlcNAc, and product complex with UDP-3-O-(R-3-hydroxydecanoyl)-GlcNAc. Catalytic His121 is involved in activating the UDP-GlcNAc 3-hydroxyl group for nucleophilic attack during the reaction. Met169 serves to constrain the length of the acyl chain and thus functions as the so-called hydrocarbon ruler. The purported oxyanion hole, formed by the backbone amide group of Gly139, displays a different conformation in Pseudomonas aeruginosa LpxA, which suggests flexibility of this structural feature important for catalysis and the potential need for substrate-induced conformational change in catalysis | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | A6V1E4 | - |
- |
Pseudomonas aeruginosa PA7 | A6V1E4 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
LpxA | - |
Pseudomonas aeruginosa |