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Literature summary for 2.3.1.13 extracted from

  • Badenhorst, C.P.; van der Sluis, R.; Erasmus, E.; van Dijk, A.A.
    Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation (2013), Expert. Opin. Drug Metab. Toxicol., 9, 1139-1153.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E226Q active site mutant Homo sapiens
F168L the variant has a lower relative activity than the wild type enzyme Homo sapiens
K16N the variant has a greater relative activity than the wild type enzyme Homo sapiens
N156S the variant has a greater relative activity than the wild type enzyme Homo sapiens
R131H the variant has a greater relative activity than the wild type enzyme Homo sapiens
R199C the variant has a lower relative activity than the wild type enzyme Homo sapiens
S17T the variant has a lower relative activity than the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + glycine Homo sapiens
-
CoA + N-acylglycine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6IB77
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + glycine
-
Homo sapiens CoA + N-acylglycine
-
?
benzoyl-CoA + glycine
-
Homo sapiens CoA + N-benzoylglycine
-
?

Subunits

Subunits Comment Organism
monomer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
GlyAT
-
Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme activity affects mitochondrial ATP production, glycine availability, free coenzyme A availability, and the toxicity of various organic acids Homo sapiens
physiological function the enzyme plays a role in liver cancer and musculoskeletal development Homo sapiens