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Literature summary for 2.3.1.135 extracted from
- Lecithin:retinol acyltransferase and retinyl ester hydrolase activities are differentially regulated by retinoids and have distinct distributions between hepatocyte and nonparenchymal cell fractions of rat liver (1997), J. Nutr., 127, 218-224.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| N-(4-hydroxyphenyl)-retinamide | restores normal level of LRAT activity in vitamin A depleted rats | Rattus norvegicus |  |
| N-(4-hydroxyphenyl)-retinamide | necessary dose, 0.5 mg | Rattus norvegicus | |
| retinol | - |
Rattus norvegicus | |
| Vitamin A | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
vitamin A deficient and sufficient diet fed | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | nonparenchymal cells LRAT activity is approximately 10 fold greater than the hepatocyte LRAT activity from both vitamin A-sufficient and retinoid acid treated vitamin A-depleted rats | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0000001 | - |
nonparenchymal cell fraction LRAT activity and hepatocyte cell fraction LRAT activity for vitamin A-deficient rats | Rattus norvegicus |
| 0.0000012 | - |
hepatocyte cell fraction LRAT activity for vitamin A-deficient rats treated with retinoic acid | Rattus norvegicus |
| 0.000003 | - |
hepatocyte fraction LRAT activity of vitamin A-sufficient rats | Rattus norvegicus |
| 0.0000054 | - |
hepatocyte cell fraction LRAT activity for vitamin A-deficient rats treated with N-(4-hydroxyphenyl)-retinamide | Rattus norvegicus |
| 0.0000132 | - |
nonparenchymal cell fraction LRAT activity for vitamin A-deficient rats treated with retinoic acid | Rattus norvegicus |
| 0.0000309 | - |
nonparenchymal cell fraction LRAT activity for vitamin A-sufficient rats | Rattus norvegicus |
| 0.0000553 | - |
nonparenchymal cell fraction LRAT activity for vitamin A-deficient rats treated with N-(4-hydroxyphenyl)-retinamide | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + retinol-(cellular-retinol-binding-protein) | - |
Rattus norvegicus | 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) | - |
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