Any feedback?
Literature summary for 2.3.1.135 extracted from
- Lecithin retinol acyltransferase is a founder member of a novel family of enzymes (2003), Biochemistry, 42, 12805-12812.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + 11-cis-retinol | Homo sapiens | essential for generation of the precursor for 11-cis-retinal, the visual chromophore in the eye | 2-acylglycerophosphocholine + 11-cis-retinyl acyl ester | - |
? |  |
| phosphatidylcholine + all-trans-retinol | Homo sapiens | enzyme is involved in vitamin A storage and mobilization | 2-acylglycerophosphocholine + all-trans-retinyl acyl ester | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95237 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | C161 and H60 form a catalytic dyad essential for activity, Q177 and D67 may play a non-essential role in catalysis, identification of the active site, reaction mechanism | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + 11-cis-retinol | - |
Homo sapiens | 2-acylglycerophosphocholine + 11-cis-retinyl acyl ester | - |
? | |
| phosphatidylcholine + 11-cis-retinol | essential for generation of the precursor for 11-cis-retinal, the visual chromophore in the eye | Homo sapiens | 2-acylglycerophosphocholine + 11-cis-retinyl acyl ester | - |
? | |
| phosphatidylcholine + all-trans-retinol | enzyme is involved in vitamin A storage and mobilization | Homo sapiens | 2-acylglycerophosphocholine + all-trans-retinyl acyl ester | - |
r | |
| phosphatidylcholine + all-trans-retinol | all-trans-retinol is vitamin A, phosphatidylcholine is lecithin | Homo sapiens | 2-acylglycerophosphocholine + all-trans-retinyl acyl ester | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lecithin retinol acyltransferase | - |
Homo sapiens |
| LRAT | - |
Homo sapiens |
| More | enzyme is the founder of a novel Cys-His enzyme family | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
