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Literature summary for 2.3.1.135 extracted from

  • Batten, M.L.; Imanishi, Y.; Maeda, T.; Tu, D.C.; Moise, A.R.; Bronson, D.; Possin, D.; Van Gelder, R.N.; Baehr, W.; Palczewski, K.
    Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004), J. Biol. Chem., 279, 10422-10432.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics the Lrat knockout mutant mice may serve as animal model with early onset severe retinal dystrophy and severe retinyl ester deprivation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene Lrat, vector cloning for construction of knockout mutants Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information gene Lrat disruption by targeted recombination for generation of a homozygous knockout mutant, the mutant mice develop normally, but the rod outer segments in the retina are about 35% shorter than those of wild-type mice, rod and cone visual functions are severely attenuated at an early age Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] Mus musculus lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters and the retinoid cycle in the eye and in the liver 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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gene Lrat
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium retinal, pigmented Mus musculus
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liver
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Mus musculus
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additional information determination of retinoid levels in liver, blood, and lung of wild-type and knockout mutant mice Mus musculus
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retina pigmented epithelial cells Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein]
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Mus musculus 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
?
phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters and the retinoid cycle in the eye and in the liver Mus musculus 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
?

Synonyms

Synonyms Comment Organism
lecithin-retinol acyltransferase
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Mus musculus
LRAT
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Mus musculus