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Literature summary for 2.3.1.136 extracted from
- Escherichia coli K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus (2005), Proc. Natl. Acad. Sci. USA, 102, 5564-5569.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene neuO, allelic variants, DNA and amino acid sequence determination and analysis, the enzyme is genetically linked to the endo-neuraminidase tail protein gene of a chromosomal accretion element CUS-3, genetic structure, role of heptanucleotide repeat regions, overview | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | deletion of gene neuO in strain EV291 eliminates enzyme activity, which can be complemented in trans, mutagenesis method, overview, nonfunctional enzyme encoded by inserted gene neuO-4 allele from unequal or mispairing recombination, GenBank AY779019, role of redistribution variant neuO alleles in pathogen evolution, function of localized hypermutability | Escherichia coli |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + an alpha-2,8-linked polymer of sialic acid | Escherichia coli | - |
CoA + silaic acid acetylated at O-7 or O-9 | - |
? |  |
| acetyl-CoA + an alpha-2,8-linked polymer of sialic acid | Escherichia coli RS174 | - |
CoA + silaic acid acetylated at O-7 or O-9 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | Q58WP5 | serotype K1, gene neuO | - |
| Escherichia coli RS174 | Q58WP5 | serotype K1, gene neuO | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + an alpha-2,8-linked polymer of sialic acid | - |
Escherichia coli | CoA + silaic acid acetylated at O-7 or O-9 | - |
? | |
| acetyl-CoA + an alpha-2,8-linked polymer of sialic acid | - |
Escherichia coli RS174 | CoA + silaic acid acetylated at O-7 or O-9 | - |
? | |
| additional information | the enzyme does not require constant association with its substrate for activity | Escherichia coli | ? | - |
? | |
| additional information | the enzyme does not require constant association with its substrate for activity | Escherichia coli RS174 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | enzyme consists of a catalytic and a non-catalytic domain encoded by a tandem heptanucleotide repeat region | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NeuO | - |
Escherichia coli |
| polysialic acid O-acetyltransferase | - |
Escherichia coli |
| polysialic acid O-AcTase | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Escherichia coli |
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Release 2023.1 (January 2023)
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