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Literature summary for 2.3.1.137 extracted from
- Carnitine octanoyltransferase of mouse liver peroxisomes: properties and effect of hypolipidemic drugs (1983), Arch. Biochem. Biophys., 222, 123-132.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.069 | - |
palmitoyl-CoA | - |
Mus musculus |  |
| 0.1 | - |
L-octanoylcarnitine | - |
Mus musculus | |
| 0.104 | - |
L-palmitoylcarnitine | - |
Mus musculus | |
| 0.11 | - |
CoASH | - |
Mus musculus | |
| 0.13 | - |
L-carnitine | - |
Mus musculus | |
| 0.155 | - |
acetyl-CoA | - |
Mus musculus | |
| 0.783 | - |
acetyl-L-carnitine | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Bos taurus | - |
- |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
| peroxisome | - |
Bos taurus | 5777 | - |
| peroxisome | matrix of liver peroxisomes | Mus musculus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Mus musculus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Rattus norvegicus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Bos taurus | - |
acyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Mus musculus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Rattus norvegicus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Bos taurus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Mus musculus | - |
L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Rattus norvegicus | - |
L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Bos taurus | - |
L-carnitine + octanoyl-CoA | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Bos taurus | - |
beef | - |
| Mus musculus | - |
fed lipid-lowering drug diet containing clofibrate, nafenopin or Wy-14,643 | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.072 | - |
- |
Mus musculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, freezing causes a 90% loss of activity within 2 days | Mus musculus |
| -80°C, freezing causes a 90% loss of activity within 2 days | Mus musculus |
| 20°C, 10 mM sodium diphosphate buffer at pH 7.5, stable for months | Mus musculus |
| 4°C, 10 mM sodium diphosphate buffer at pH 7.5, stable for months | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + L-carnitine | - |
Mus musculus | acetyl-L-carnitine + CoA | - |
r | |
| acetyl-CoA + L-carnitine | - |
Rattus norvegicus | acetyl-L-carnitine + CoA | - |
r | |
| acetyl-L-carnitine + CoA | - |
Mus musculus | acetyl-CoA + L-carnitine | - |
r | |
| acetyl-L-carnitine + CoA | - |
Rattus norvegicus | acetyl-CoA + L-carnitine | - |
r | |
| acyl-CoA + L-carnitine | - |
Mus musculus | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Bos taurus | acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | - |
Mus musculus | acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | - |
Rattus norvegicus | acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | - |
Bos taurus | acyl-CoA + L-carnitine | - |
r | |
| CoA + L-octanoylcarnitine | - |
Mus musculus | octanoyl-CoA + L-carnitine | - |
r | |
| CoA + L-palmitoylcarnitine | - |
Mus musculus | palmitoyl-CoA + L-carnitine | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Mus musculus | octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Rattus norvegicus | octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Bos taurus | octanoyl-L-carnitine + CoA | - |
r | |
| octanoyl-L-carnitine + CoA | - |
Mus musculus | L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | - |
Rattus norvegicus | L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | - |
Bos taurus | L-carnitine + octanoyl-CoA | - |
r | |
| palmitoyl-CoA + L-carnitine | - |
Mus musculus | L-palmitoyl-L-carnitine + CoA | - |
r | |
| palmitoyl-CoA + L-carnitine | - |
Rattus norvegicus | L-palmitoyl-L-carnitine + CoA | - |
r | |
| palmitoyl-L-carnitine + CoA | - |
Mus musculus | palmitoyl-CoA + L-carnitine | - |
r | |
| palmitoyl-L-carnitine + CoA | - |
Rattus norvegicus | palmitoyl-CoA + L-carnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Bos taurus |
| monomer | 1 * 60000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COT | - |
Mus musculus |
| COT | - |
Rattus norvegicus |
| COT | - |
Bos taurus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.367 | - |
octanoyl-CoA | - |
Mus musculus | |
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